The Institute of Public Health responded to a consultation, launched by the Department of Health in Northern Ireland in October 2021, on developing a new 10-year cancer strategy. It focuses on four key themes: cancer prevention, diagnosis and treatment, patient experience and strategy implementation in Northern Ireland. Key Observations In this submission, the Institute made a series of recommendations, including the benefits of investing in cancer prevention and reduction of modifiable risk factors, the need for a clear roadmap for transformational change, greater collaboration and knowledge sharing with Great Britain and Ireland, and the need to address and reduce health inequalities. The Institute also highlighted the need to improve health literacy and communications around cancer, and to address systematic barriers to cancer care. A programme of research to gather intelligence on the underlying reasons for low cancer survival would be welcomed to identify salient intervention points and inform prioritisation.